Additional Information:
UFHPL Epic order code: LAB5851
For each required FISH analysis, select the entire panel or customize your own panel.
If the probe is unspecified, call UF Health Pathology Laboratories at 888.375.LABS (5227) for availability.
Chromosome Studies
Chromosome Study: Neoplastic Lymphatic Tissue: Change Turn Around Time to 10-28 days
Chromosome Study: Neoplastic Marrow/Blood: Change to 7-21 days
Chromosome Study: Neoplastic Solid Tumor: Change to 10-28 days
Chromosome Study: Products of Conception: (good)
Chromosome Study: Routine Peripheral Blood: good but add 7-10 day turn around for newborns (one month or less)
Chromosome Study: Solid Tissue (for Constitutional Congenital Studies): Change to 14-28 days
FISH Panels
Myelodysplastic syndrome (MDS)
EGR1 (del 5q/mono 5)
D7S522 (del 7q/mono 7)
D8Z2
D20S108 (del 20q)
Acute myeloid leukemia (AML)
RUNX1T1/RUNX1 [t(8;21)]
BCR/ABL1 [t(9;22)]
KMT2A
CBFB
TP53
AML COG
RUNX1T1/RUNX1 [t(8;21)]
KMT2A
Acute lymphoid leukemia (ALL) COG standard risk
BCR/ABL1 [t(9;22)]
KMT2A
ETV6/RUNX1 [t(12;21)]
CEP 4/CEP 10
ALL COG high risk
Std risk PLUS:
ABL2
PDGFRB
ABL1
ALL pediatric non-COG
TCF3/PBX1 [t(1;19)]
CKDN2A (del 9p)
BCR/ABL1 [t(9;22)]
KMT2A
ETV6/RUNX1 [t(12;21)]
CEP 4/CEP 10
ALL adult
TCF3/PBX1 [t(1;19)]
BCR/ABL1 [t(9;22)]
KMT2A
ETV6/RUNX1 [t(12;21)]
Plasma cell neoplasm (PCN) or multiple myeloma (MM)
CKS1B (1q)
D13S319 (del 13q/mono 13)
IGH
TP53
Chronic lymphocytic leukemia (CLL)
ATM (del 11q)
D12Z3
D13S319 (del 13q/mono 13)
TP53
Myeloproliferative neoplasm (MPN) w/ eosinophilia
BCR/ABL1 [t(9;22)]
ETV6
PDGFRb
NHL
BCL6
MYC
IGH/CCND1 [t(11;14)]
BCL2
T-ALL or mixed lineage leukemia
BCR/ABL1 [t(9;22)]
KMT2A
FISH Study: Microdeletion Metaphase – DiGeorge Syndrome (22q11.2): combine with VCF; 7-21 days
Rename to: FISH Study: 22q11.2 Microdeletion Syndrome (DiGeorge/VCF)
FISH Study: Microdeletion Metaphase – SRY Sex Determination (Yp11.3): 7-21 days
Rename to: FISH Study: SRY Sex Determination
ADD – FISH Study: X/Y Sex Chromosome Determination: 7-21 days
FISH Study: Neoplastic Interphase MLL: change MLL to KMT2A
FISH Study: Neoplastic Interphase RB1 with LAMP1 (Deletion 13q): Remove, no longer done
FISH Study: Remove all of these, no longer done
TAT on all FISH tests, currently at 5-12 days
Change to 7-10 days
Methodology:
Fluorescence in-situ hybridization (FISH)