Comprehensive Endocrine Autoantibodies Panel

Additional Information:

EPIC Test Name: COMPREHENSIVE ENDOCRINE AUTOANTIBODY PANEL
EPIC order code: LAB12300013

This panel includes the following tests:
Adrenal Cortical Autoantibodies
Gastric Parietal Cell Autoantibodies
Glutamic Acid Decarboxylase Autoantibodies (GADA)
Insulin Autoantibodies (IAA)
Insulinoma Associated-2 Autoantibodies (IA-2A)
Islet Cell Autoantibodies
Thyroglobulin Autoantibodies (TGA)
Thyroperoxidase Autoantibodies (TPOA)
Zinc Transporter 8 Autoantibody (ZnT8A)

CPT Code(s):

  • 88346
  • 88350 (x 2)
  • 86341 (x 3)
  • 86337
  • 86800
  • 86376

Specimen Requirements:

Type: Serum
Container/Tube: SST
Sample Volume: 3 mL
Minimum Volume: 1 mL (Repeat testing is not possible with this specimen volume.)
Storage: Centrifuge, separate and transfer the serum to a plastic vial. Ship specimens with a frozen cold pack for overnight delivery.
Stability (collection to time of analysis/testing):

  • Refrigerated: 24 hours
  • Frozen: 1 year

Use:

  • Diagnosis of an Autoimmune Endocrine Disorder: In the presence of clinical endocrine disease, an autoantibody directed against the affected gland indicates an autoimmune etiology for the glandular dysfunction.
  • Prediction of an Autoimmune Endocrine Disorder: Endocrine autoantibodies detected in an asymptomatic individual indicate an increased risk for the subsequent development of clinical endocrine disease.

Methodology:

Indirect Immunofluorescence (ICA, Adreno-Cort Ab, Gastric Parietal Ab), Radioimmunoassay (IA-2A, IAA, TGA, TPOA), Enzyme-linked Immunosorbant Assay (GADA, ZnT8A)

Reported:

7-20 days

Reference Values:

ADRENO-CORT AB Ref. Range: Negative
GAST PARIETAL AB Ref. Range: Negative
ISLET CELL ANTIBODY Ref. Range: 0.0, 5.0 JDF
THYROGLOBULIN AB Ref. Range: <1.0 U/mL
THYROID PEROXIDASE ANTIBODIES Ref. Range: <1.0 U/mL
IA2 AUTOANTIBODIES (ISLET) Ref. Range: 0.00-<0.90 U/mL
ZINC T8 AUTOANTIBODY Ref. Range: ≤ 15.0 U/mL
INSULIN AUTOANTIBODY Ref. Range: 0-94 nU/mL
GLUTAMIC ACID DECARBOXYLASE ANTIBODY Ref. Range: <5.0 IU/mL

Performed:

Weekly (TGA, TPOA), Bi-Weekly (ICA, Adreno-Cort Ab, Gastric Parietal Ab, IA-2A, GADA, ZnT8) and Monthly (IAA)